About prof. dr. Jan H.J. Hoeijmakers

Research of Jan Hoeijmakers focuses on DNA repair and the impact of nutrition on cancer and aging. His team made major contributions to cloning human repair genes, elucidating underlying mechanisms, and generating numerous mouse mutants mimicking rare human repair syndromes. 

He discovered that accumulating DNA damage causes transcription stress and aging but at the same time triggers a potent anti-aging ‘survival’ response, that resembles calorie restriction (CR). Applying 30% CR dramatically delayed accelerated aging in mouse repair mutants by reducing DNA damage and its sequelae, explaining the anti-aging, anti-cancer mechanism of CR. Translation to the progeroid DNA repair patients even surpassed the enormous benefits in mice, revising nutritional guidelines for these syndromes. The clinical implications extend to counteracting neurodegeneration, side effects of chemo/radiotherapy, and surgery-related ischemia reperfusion injury. 

He heads research teams in the Erasmus Medical Center (Rotterdam), Princess Máxima Center for Pediatric Oncology (Utrecht) and CECAD (Cologne).

Prof. dr. Jan Hoeijmakers
Prof. dr. Jan H.J. Hoeijmakers

Keynote address Genetics Retreat 2024
DNA damage and Aging: from Insight to Intervention

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